Detecting Selection from Linked Sites Using an F-Model
نویسندگان
چکیده
منابع مشابه
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Natural selection at linked sites in humans.
Theoretical and empirical work indicates that patterns of neutral polymorphism can be affected by linked, selected mutations. Under background selection, deleterious mutations removed from a population by purifying selection cause a reduction in linked neutral diversity. Under genetic hitchhiking, the rise in frequency and fixation of beneficial mutations also reduces the level of linked neutra...
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An excess of nonsynonymous over synonymous substitution at individual amino acid sites is an important indicator that positive selection has affected the evolution of a protein between the extant sequences under study and their most recent common ancestor. Several methods exist to detect the presence, and sometimes location, of positively selected sites in alignments of protein-coding sequences...
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ژورنال
عنوان ژورنال: Genetics
سال: 2020
ISSN: 1943-2631
DOI: 10.1534/genetics.120.303780